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Memory loss from Zoloft? Here's What You Need to Know

memory loss Apr 20, 2023
Woman holding a pill and glass of water, asking can Zoloft cause memory loss?

Memory loss is an alarming concern and one that is often linked to the use of certain medications. Zoloft is an antidepressant that is commonly prescribed to treat depression, anxiety, and other mental health issues. But does Zoloft cause memory loss? 

In this article, we explore memory loss from the use of Zoloft and the steps you can take if you experience memory problems. Additionally, we'll discuss natural remedies to help your memory. By the end of this article, you'll have a better understanding of memory loss from Zoloft and how to make sure that you don't trade mental health concerns for memory problems.

Mental Health Conditions and Memory Problems

At baseline, mental health conditions can have a significant impact on memory and cognitive functioning.

Memory problems can be a symptom of depression, anxiety disorders, and/or PTSD. These memory problems can be caused by a variety of factors, including changes in the brain’s structure and function, low levels of certain neurotransmitters, and of course, medication side effects. 

Zoloft is a prescription medication often used to treat these mental health conditions. 

What is Zoloft?

Zoloft is an antidepressant medication that belongs to a class of drugs called selective serotonin reuptake inhibitors (SSRIs).

It is used to treat a variety of mental health conditions including:

  • Depression or major depressive disorder
  • Obsessive-compulsive disorder (OCD)
  • Post-traumatic stress disorder (PTSD)
  • Social anxiety disorder 
  • Panic disorder or panic attacks
  • Premenstrual Dysphoric Disorder (PMDD)
  • Bipolar disorder


How it Works

Zoloft works by increasing levels of serotonin, a chemical messenger that helps regulate your mood, appetite, and sleep. While Zoloft can be beneficial for treating mental health issues, it (like most other prescription medications) can come with serious side effects, including memory problems.


What Are The Side Effects of Zoloft?

Despite the potential usefulness of SSRIs, they could cause unwanted side effects such as headaches, weight gain, sexual dysfunction, changes in sleep patterns, and gastrointestinal problems. While SSRIs were initially thought to not cause cognitive impairment, there is now conflicting evidence regarding this side effect, and many patients report experiencing memory problems while taking SSRIs.

In addition to memory problems from the effects of sertraline, many of the common side effects of Zoloft, such as poor sleep and GI trouble, can also contribute to memory problems and brain fog.

Most Common Side Effects of Zoloft include:

  • Drowsiness and fatigue
  • Trouble sleeping or insomnia
  • Gastrointestinal problems
  • Weight gain or weight loss
  • Dizziness
  • Upset stomach, dry mouth, and changes in appetite
  • Sexual dysfunction

Obligatory medical disclaimer: It's important to talk to your healthcare provider and to seek medical attention if you experience sudden changes with the medication such as agitation, suicidal thoughts, hallucinations, fever, nausea, vomiting, fast heart rate, chest pain, trouble concentrating, slurred speech, or weakness.



Why Does Zoloft Cause Memory Problems?

Memory loss can be a daunting side effect for patients taking Zoloft, causing them to become less likely to adhere to the medication regimen. But why does it happen?

This 2016 study, Cognitive Function Before and During Treatment with Selective Serotonin Reuptake Inhibitorslooked at the cognitive function of 50 people (ages 20-60) diagnosed with depression or obsessive compulsive disorder. They were given an assessment before and after taking an SSRI drug, called the Mini-Mental State Examination (MMSE). This assessment showed that the participant's scores decreased over time, suggesting that taking these SSRI drugs could acutely impact memory and thinking skills.

Findings from this study indicated statistically significant memory loss during the 8 weeks of treatment. In other words, if you're taking Zoloft and wondering why you can't remember things, you're not imagining it.

And while memory problems can result from mental health disorders themselves, the study results indicate that memory loss appears to be more likely due to SSRI therapy rather than depression symptoms. 

Although this study provides insight into the potential cause of memory loss due to SSRIs, more research is needed to understand exactly what is causing this side effect.

Risk Factors for Memory Loss from Zoloft

There are several risk factors for memory loss from Zoloft. These include age, pre-existing mental health conditions, and the dosage of the medication.

Older adults are at higher risk of memory problems than younger people. Additionally, the dosage of the medication can also impact the risk of memory loss. Higher doses of Zoloft have been associated with an increased risk of memory loss. It is important to talk to your doctor about the risks and benefits of Zoloft to ensure that you are taking the lowest possible dose that is effective.

Medication Side Effects Can Also Lead to Memory Problems

Medication side effects can also lead to memory problems. In addition to the potential for memory loss from Zoloft, many of its adverse effects, such as insomnia, low appetite, and GI problems, can also contribute to difficulty with attention and memory. 

Can Prolonged Use of Antidepressants Increase Your Risk of Dementia and Alzheimer's Disease?

Prolonged use of antidepressants can increase your risk of developing dementia and Alzheimer's disease.

While it isn't a cause-and-effect relationship, research has shown that people who use antidepressants for a long period of time are two times more likely to experience mild cognitive impairment or dementia than those who do not take antidepressants. This includes popular SSRIs such as Prozac, Lexapro, and Zoloft. 

This association was especially strong for people who take antidepressants before the age of 65. If you're taking an SSRI, it's important to be aware of this association and to be as proactive as possible in protecting your cognitive health.

What Can You Do if You Experience Memory Loss from Zoloft?

Memory loss from the use of Zoloft can be frightening and frustrating, but there are steps you can take to help manage the symptoms. If you experience any memory loss while taking Zoloft, talk to your doctor as soon as possible. Your doctor can help to evaluate your symptoms, adjust your dosage, and suggest possible solutions. 

Additionally, there are natural remedies that may help to lessen the symptoms of memory loss. These include lifestyle changes, such as exercising regularly, eating a brain-healthy diet, and getting enough sleep. Taking supplements to support your brain health, such as vitamin B12, vitamin D, and/or Magnesium can also help combat brain fog.

Read more about the 6 Best Vitamins and Supplements for Brain Fog here.

By taking the necessary steps to manage your mental health, you can reduce the risk of experiencing memory loss from Zoloft and maintain your overall well-being.

Memory Health Coaching

If you are experiencing memory problems from Zoloft, I'd love to help. As a memory health coach for women, I understand the importance of balancing brain health, cognitive function, and mental health. I offer a free consultation call to discuss how I can help you overcome your memory problems and protect your mental health. Schedule a call today to see if memory health coaching is a good fit for you.




Zoloft is a beneficial treatment for many mental health issues, but taking some SSRIs can also lead to memory problems. It is important to understand your potential risks of memory problems from Zoloft so that you can take the necessary steps to protect your mental health.

If you experience any memory problems while taking Zoloft, talk to your doctor and consider incorporating natural remedies to help lessen the impact. By understanding the potential risks and taking the necessary steps, you can ensure that your mental health stays a priority. 

*The information in this article is not medical advice. Please consult with your doctor for medical help.

Questions? Contact Francine Here

Meet the Coach

Hey there! I'm Francine, a speech-language pathologist turned memory health coach with a passion for helping you overcome your memory problems.

In my practice, I help women just like you trade memory problems for confidence and clarity everyday so you can think clearly and remember easily, without constant self-doubt weighing you down. 

If you're struggling with poor recall and foggy thinking, you're in the right place and I want to help you!


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